Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice

L Tribolet; AM Brice; TS Fulford; DS Layton; DI Godfrey; AGD Bean; CR Stewart

Journal article

Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice

L Tribolet, AM Brice, TS Fulford, DS Layton, DI Godfrey, AGD Bean, CR Stewart

Immunobiology | Elsevier BV | Published : 2023

DOI: 10.1016/j.imbio.2023.152380

Abstract

Inflammation and lipid regulator with UBA-like and NBR1-like domains (ILRUN) is a protein-encoding gene associated with innate immune signaling, lipid metabolism and cancer. In the context of innate immunity, ILRUN inhibits IRF3-mediated transcription of antimicrobial and proinflammatory cytokines by inducing degradation of the transcriptional coactivators CBP and p300. There remains a paucity of information, however, regarding the innate immune roles of ILRUN beyond in vitro analyses. To address this, we utilize a knockout mouse model to investigate the effect of ILRUN on cytokine expression in splenocytes and on the development of immune cell populations in the spleen and thymus. We show e..

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